HEAD-ONLY STUNNING OF TURKEYS PART 2: SUBJECTIVE AND OBJECTIVE ASSESSMENT OF THE APPLICATION OF AC AND DC WAVEFORMS

Head-Only Stunning of Turkeys Part 2: Subjective and Objective Assessment of the Application of AC and DC Waveforms

Electrical stunning is likely to remain an important stunning method for turkeys at slaughter.The purpose of this study is to understand the application of various waveforms of alternating current (AC) and pulsed direct currents (DC), head-only, to turkeys and to improve the effectiveness of handheld stunning of turkeys.We evaluated the Sippy Cups

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Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

Abstract The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4.We show here that S.cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones and that these mutations are sufficient for

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Inhibitory receptor expression depends more dominantly on differentiation and activation than exhaustion of human CD8 T cells

Under conditions of chronic antigen stimulation, such as persistent viral infection and cancer, CD8 T cells may diminish effector function, which has been termed exhaustion.Expression of inhibitory Receptors (iRs) is often regarded as a hallmark of exhaustion.Here we studied the expression of eight different iRs by CD8 T cells of healthy humans, in

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Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila.

The activation of several transcription factors is required for the elimination of infectious pathogens via the innate immune response.The transcription factors NF-kappaB, AP-1, and STAT play major roles in the synthesis of immune effector Dusters molecules during innate immune responses.However, the fact that these immune responses can have cytoto

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